I suggest you turn off Joomla! caching as it is known to cause some problems. I think you may mean the setting in configuration.php, which relate to Joomla!, not php.ini, which has the php settings.
My settings for the cache in configuration.php are as follows:
public $caching = '0';
public $cache_handler = 'file';
public $cachetime = '15';
public $cache_platformprefix = '0';
But it is better to just turn off Joomla! caching in Global Config - System tab whenever you find you may have a problem. Also of course disable any Cache extension you may have installed.